Targeting Epigenetics: An Epicenter of Oncology Drug Discovery?
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چکیده
منابع مشابه
Epigenetics at the epicenter of modern medicine.
Epigenetics, the study of non-DNA sequence-related heredity, is at the epicenter of modern medicine because it can help to explain the relationship between an individual's genetic background, the environment, aging, and disease. It can do so because the epigenetic state varies among tissues and during a lifetime, whereas the DNA sequence remains essentially the same. As cells adapt to a changin...
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Anesthesiology, V 123 • No 4 743 October 2015 C onrad Hal Waddington (1905–1975), a British embryologist, geneticist, and philosopher, proposed the concept of epigenetics, defined broadly as the bridge between an organism’s inheritable genome and the observable traits of that organism, such as morphology, physiological properties, and behavior.1 For example, although a majority of a given organ...
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We have made remarkable progress in our understanding of the pathophysiology of cancer. This improved understanding has resulted in increasingly effective targeted therapies that are better tolerated than conventional cytotoxic agents and even curative in some patients. Unfortunately, the success rate of drug approval has been limited, and therapeutic improvements have been marginal, with too f...
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Cancer is caused by aberrant genetic and epigenetic changes in genes expression. DNA methylation, histone modification, and microRNAs gene deregulation are the most known epigenetic changes in different stages of cancer. Since every tumor has its own specific epigenome, any abnormal pattern is a potential biomarker for classification of different types of tumors. Despite, tumorigenesis, abnorma...
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ژورنال
عنوان ژورنال: AACR Education book
سال: 2013
ISSN: 1943-6475
DOI: 10.1158/aacr.edb-13-7805